SparingVision Conference Participation in H1 2025
Paris, 11 December, 2024 – SparingVision (“the Company”), a clinical-stage genomic medicine company transforming the treatment of retinal disease, today announces upcoming conferences that its management team will be participating in in the first half of 2024:
Investor and Industry Conferences:
JP Morgan 43rd Annual Healthcare Conference, San Francisco, California, US – 13-16 January
Gene Therapy Development Summit 2025, Boston, Massachusetts, US – 26-29 March
25th Bio€quity Europe, Bruges, Belgium – 12-14 May
Scientific & Medical Conferences:
Hawaiian Eye & Retina, Maui, Hawaii, US – 18-24 January
Macula Society Annual Conference, Charlotte Harbor, Florida, US – 12-15 February
Argentina National Ophthalmology Congress, Buenos Aires, Argentina – 3-5 April
ARVO (Association for Research in Vision and Ophthalmology), Salt Lake City, Utah, US – 4-8 May
ASGCT (American Society of Gene and Cell Therapy), New Orleans, Louisiana, US – 13-17 May
Festival of Biologics, San Diego, CA, US – 23-24 April
Patient Associations Conferences:
Investing in the Cures Summit, Tampa, Florida, US – 22 March
Retinal Therapeutics Innovation Summit, Salt Lake City, Utah, US – 2 May
**ENDS**
NOTES TO EDITORS:
About SparingVision
SparingVision is a global ophthalmology leader bringing new hope to millions affected by retinal diseases, for which there are currently no viable treatments. The Company has assembled a suite of cutting-edge technologies from gene therapy to CRISPR, enabling it to deploy the right technology to the right disease and ensure the delivery of breakthrough treatments to millions of patients.
Both of its investigational products, SPVN06 and SPVN20 go beyond single gene correction therapies to deliver new gene-agnostic treatments for Retinitis Pigmentosa, a group of inherited retinal diseases which are one of the leading cause of blindness globally. The Company also has a strategic collaboration with Intellia Therapeutics (NASDAQ:NTLA) to develop novel genome editing-based treatments for ocular disease utilizing CRISPR-Cas9 technology.
SparingVision is a spin-off from the Paris Vision Institute and backed by high-quality international investors including 4BIO Capital, Advent France Biotechnology, Bpifrance, Foundation Fighting Blindness (US), Fondation Voir & Entendre, Intellia Therapeutics, UPMC Enterprises, Jeito Capital and Ysios Capital.
Visit www.sparingvision.com for more and follow us on LinkedIn and X (formerly Twitter) @SparingVision
About SPVN06
SPVN06 is a proprietary, mutation-agnostic, AAV vector based investigational gene therapy approach comprised of one neurotrophic factor (Rod derived Cone Viability Factor, RdCVF) and one enzyme reducing oxidative stress (Rod derived Cone Viability Factor Long form, RdCVFL). Acting synergistically, RdCVF and RdCVFL aim at slowing or stopping the degeneration of cone photoreceptors, which inevitably leads to blindness in patients with rod-cone dystrophies (RCD). SparingVision’s primary disease targets are retinitis pigmentosa (RP), one of the most common inherited retinal diseases that affects an estimated two million patients worldwide and dry Age-related Macular Degeneration (AMD). There is currently no treatment approved to treat RP patients independently of their genetic background. This approach is potentially applicable to many more diseases, where the loss of rods is known to be an early signal of the disease. SPVN06 is the result of decades of world-leading ophthalmology research by SparingVision founders José-Alain Sahel and Thierry Léveillard at the Paris Vision Institute.
About PRODYGY
PRODYGY (Promising ROd-cone DYstrophy Gene therapY) is a multicentric Phase I/II trial to assess the safety, tolerability as well as preliminary efficacy and quality-of-life following a single subretinal injection of SPVN06 in the worst-seeing eye of adult patients with RCD due to a mutation in the RHO, PDE6A, or PDE6B gene. Further information on the PRODYGY trial can be found on www.ClinicalTrials.gov (CT identifier: NCT05748873).
About PHENOROD2
The PHENOROD2 study is one of the largest prospective natural history studies ever conducted in patients with rod-cone dystrophy (RCD) due to a variant in the gene RHO, PDE6A, or PDE6B. A cohort of 80 patients was recruited regardless of their disease duration, provided they were not legally blind, as defined by a best-corrected visual acuity (BCVA) of ≥ 20/200 in at least one eye and retained a horizontal diameter of binocular visual field ≥ 5°. The follow-up of PHENOROD2 patients continues, and covariate analyses will be conducted to examine specific patient populations more closely.
Identification of structural markers of accelerated degeneration in certain patients is an important finding for therapies like SPVN06 looking to promote cone survival and slow down disease progression. It is of high interest for the ongoing Phase I/II trial PRODYGY which will assess the safety and preliminary efficacy of SPVN06 at 12 months using the same markers among others. SPVN06 is a breakthrough gene-agnostic investigational gene therapy approach aimed at stopping or slowing disease progression in patients affected by RCD. Exploratory efficacy assessment in the PRODYGY Phase I/II trial will include a descriptive comparison to PHENOROD2 findings.
Further information on the PHENOROD2 trial can be found on www.ClinicalTrials.gov (CT identifier: NCT04285398).