SparingVision Reports Positive Initial Safety Data from the first cohort treated in its PRODYGY Phase I/II Gene Therapy Trial
- Lead gene therapy asset, SPVN06, reported to be well-tolerated in first dosed cohort at low dose with a favorable safety profile
- Positive recommendation received from Data Safety Monitoring Board (DSMB) to dose second cohort at the medium dose
Paris, August 30, 2023 – SparingVision (“the Company”), a clinical-stage genomic medicine company developing vision-saving treatments for ocular diseases, today announced positive initial safety data from the Phase I/II clinical trial (‘PRODYGY’, NCT05748873) of SPVN06, the Company’s lead gene-agnostic gene therapy for the treatment of retinitis pigmentosa (RP). SPVN06 is a breakthrough gene therapy approach aimed at stopping or slowing disease progression in patients affected by rod-cone dystrophy, (RCD), regardless of their genetic background. SparingVision is initially focusing on mid-stage RP, one of the leading inherited causes of blindness globally.
Safety data collected on the first three patients (cohort 1) treated with a low dose showed that SPVN06 has been well tolerated with a favorable safety profile. The patients were each injected at the 15-20 National Hospital in Paris, France. Following review of the data, the Data Safety Monitoring Board (DSMB) concluded that it is safe to initiate the second cohort at a medium dose.
Stéphane Boissel, President and Chief Executive Officer of SparingVision, said: “We are committed to saving sight with pioneering genomics and firmly believe that SPVN06 has the potential to make a meaningful impact in patients’ lives and bring hope to those affected by retinitis pigmentosa. This trial is just the beginning; we have a broad pipeline of vision-saving treatments that leverage cutting edge genomic technologies that will transform current treatment of retinal disease. We look forward to reporting on the progress of SPVN06 and our other programs as we rapidly move our portfolio through development.”
Avril Daly, Chief Executive Officer of Retina International, a patient advocacy group, commented: “The positive initial safety data with SPVN06 is an important step forward for all those living with retinitis pigmentosa. As a community, we have highlighted the need for a therapy that addresses the wide range of genetic backgrounds that can cause RP for many years now. SparingVision’s approach with SPVN06 offers hope for those of us who have been impacted by this degenerative blinding disease. We are eagerly awaiting the results of this Phase I/II trial and the potential for this therapy to slow or stop the progression of RP.”
The primary endpoint of the PRODYGY Phase I/II trial is expected to be reached in 2025 and preliminary efficacy results are expected within the same year.
PRODYGY is a multicentric Phase I/II trial to assess the safety, tolerability as well as preliminary efficacy and quality-of-life following a single subretinal injection of SPVN06 in the worst-seeing eye of adult patients with RCD due to a mutation in the RHO, PDE6A, or PDE6B gene. The study will recruit a total of 33 patients, in two steps:
- Step 1: open-label, dose-escalation phase including three cohorts of three patients with severe advanced RCD, to determine two recommended best-tolerated doses for Step Two.
- Step 2: controlled, double-masked, randomized extension phase including 24 patients with intermediate advanced RP, divided into three cohorts: six untreated subjects and 18 patients receiving one of the two Recommended Doses determined in Step One.
The principal investigators of the trial are Pr. Isabelle Audo at the 15-20 National Hospital in Paris, France and Dr. Joseph Martel at the Eye Center of the University of Pittsburgh Medical Center, Pittsburgh, USA.
Further details of the trial can be found on clinicaltrials.gov under the identifier NCT05748873.
SPVN06 is a proprietary, mutation-agnostic, AAV gene therapy approach comprised of one neurotrophic factor (Rod derived Cone Viability Factor, RdCVF) and one enzyme reducing oxidative stress (Rod derived Cone Viability Factor Long form, RdCVFL). Acting synergistically, RdCVF and RdCVFL aim at slowing or stopping the degeneration of cone photoreceptors, which inevitably leads to blindness in patients with rod-cone dystrophies (RCD). SparingVision’s primary disease targets are retinitis pigmentosa (RP), one of the most common inherited retinal diseases that affects an estimated two million patients worldwide and dry Age-related Macular Degeneration (AMD). There is currently no treatment approved to treat RP patients independently of their genetic background. This approach is potentially applicable to many more diseases, where the loss of rods is known to be an early signal of the disease. SPVN06 is the result of decades of world-leading ophthalmology research by SparingVision founders José-Alain Sahel and Thierry Léveillard at the Paris Vision Institute.
Dr. Jose-Alain Sahel and UPMC have financial interests in the study sponsor, SparingVision. These financial interests mean it is possible that the results of this research could lead to personal profit for Dr. Sahel and to institutional profit for UPMC. The conflicts of interest presented by these relationships are being managed by the University and UPMC.